Structural and molecular basis of the assembly of the TRPP2/PKD1 complex

Mutations in PKD1 and TRPP2 account for nearly all cases of autosomal dominant polycystic kidney disease (ADPKD). These 2 proteins form a receptor/ion channel complex on the cell surface. Using a combination of biochemistry, crystallography, and a single-molecule method to determine the subunit comp...

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Autors principals: Yu, Yong, Ulbrich, Maximilian H., Li, Ming-Hui, Buraei, Zafir, Chen, Xing-Zhen, Ong, Albert C. M., Tong, Liang, Isacoff, Ehud Y., Yang, Jian
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710685/
https://ncbi.nlm.nih.gov/pubmed/19556541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903684106
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