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53BP1 cooperation with the REV7-Shieldin complex underpins DNA structure-specific NHEJ
53BP1 governs a specialised, context-specific branch of the classical non-homologous end joining (NHEJ) DNA double-strand break (DSB) repair pathway. 53bp1(-/-) mice are immunodeficient owing to a complete loss of immunoglobulin (Ig) class-switch recombination (CSR)(1,2), and reduced long-range V(D)...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6989217/ https://ncbi.nlm.nih.gov/pubmed/30046110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0362-1 |
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