53BP1 cooperation with the REV7-Shieldin complex underpins DNA structure-specific NHEJ

53BP1 governs a specialised, context-specific branch of the classical non-homologous end joining (NHEJ) DNA double-strand break (DSB) repair pathway. 53bp1(-/-) mice are immunodeficient owing to a complete loss of immunoglobulin (Ig) class-switch recombination (CSR)(1,2), and reduced long-range V(D)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nature
Prif Awduron: Ghezraoui, Hind, Oliveira, Catarina, Becker, Jordan R., Bilham, Kirstin, Moralli, Daniela, Anzilotti, Consuelo, Fischer, Roman, Deobagkar-Lele, Mukta, Sanchiz-Calvo, Maria, Fueyo-Marcos, Elena, Bonham, Sarah, Kessler, Benedikt M., Rottenberg, Sven, Cornall, Richard J., Green, Catherine M., Chapman, J. Ross
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989217/
https://ncbi.nlm.nih.gov/pubmed/30046110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0362-1
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