Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer

The functional consequences of somatic non-coding mutations in ovarian cancer (OC) are unknown. To identify regulatory elements (RE) and genes perturbed by acquired non-coding variants, here we establish epigenomic and transcriptomic landscapes of primary OCs using H3K27ac ChIP-seq and RNA-seq, and...

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Vydáno v:Nat Commun
Hlavní autoři: Corona, Rosario I., Seo, Ji-Heui, Lin, Xianzhi, Hazelett, Dennis J., Reddy, Jessica, Fonseca, Marcos A. S., Abassi, Forough, Lin, Yvonne G., Mhawech-Fauceglia, Paulette Y., Shah, Sohrab P., Huntsman, David G., Gusev, Alexander, Karlan, Beth Y., Berman, Benjamin P., Freedman, Matthew L., Gayther, Simon A., Lawrenson, Kate
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181647/
https://ncbi.nlm.nih.gov/pubmed/32332753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15951-0
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