VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice

BACKGROUND: Traumatic brain injury (TBI) refers to temporary or permanent damage to brain function caused by penetrating objects or blunt force trauma. TBI activates inflammasome-mediated pathways and other cell death pathways to remove inactive and damaged cells, however, they are also harmful to t...

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Veröffentlicht in:Oxid Med Cell Longev
Hauptverfasser: Sun, Zhezhe, Nyanzu, Mark, Yang, Su, Zhu, Xiaohong, Wang, Kankai, Ru, Junnan, Yu, Enxing, Zhang, Hengli, Wang, Zhenzhong, Shen, Jie, Zhuge, Qichuan, Huang, Lijie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181015/
https://ncbi.nlm.nih.gov/pubmed/32377306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/7879629
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