Phase 1 Lead-in to a Phase 2 Factorial Study of Temozolomide Plus Memantine, Mefloquine, and Metformin as Postradiation Adjuvant Therapy for Newly Diagnosed Glioblastoma

BACKGROUND: Repurposed memantine, mefloquine, and metformin have putative anticancer activity. The objective of this phase 1 study was to determine the maximum tolerated doses (MTDs) of combinations of these agents with temozolomide (TMZ). METHODS: Adults with newly diagnosed glioblastoma who comple...

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Detalhes bibliográficos
Publicado no:Cancer
Main Authors: Maraka, Stefania, Groves, Morris D., Mammoser, Aaron G., Melguizo-Gavilanes, Isaac, Conrad, Charles A., Tremont-Lukats, Ivo W., Loghin, Monica E., O’ Brien, Barbara J., Puduvalli, Vinay K., Sulman, Erik P., Hess, Kenneth R., Aldape, Kenneth D., Gilbert, Mark R., de Groot, John F., Yung, W.K. Alfred, Penas-Prado, Marta
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7180384/
https://ncbi.nlm.nih.gov/pubmed/30359477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.31811
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