Phase 1 Lead-in to a Phase 2 Factorial Study of Temozolomide Plus Memantine, Mefloquine, and Metformin as Postradiation Adjuvant Therapy for Newly Diagnosed Glioblastoma

BACKGROUND: Repurposed memantine, mefloquine, and metformin have putative anticancer activity. The objective of this phase 1 study was to determine the maximum tolerated doses (MTDs) of combinations of these agents with temozolomide (TMZ). METHODS: Adults with newly diagnosed glioblastoma who comple...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cancer
Päätekijät: Maraka, Stefania, Groves, Morris D., Mammoser, Aaron G., Melguizo-Gavilanes, Isaac, Conrad, Charles A., Tremont-Lukats, Ivo W., Loghin, Monica E., O’ Brien, Barbara J., Puduvalli, Vinay K., Sulman, Erik P., Hess, Kenneth R., Aldape, Kenneth D., Gilbert, Mark R., de Groot, John F., Yung, W.K. Alfred, Penas-Prado, Marta
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7180384/
https://ncbi.nlm.nih.gov/pubmed/30359477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.31811
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