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Phase 1 Lead-in to a Phase 2 Factorial Study of Temozolomide Plus Memantine, Mefloquine, and Metformin as Postradiation Adjuvant Therapy for Newly Diagnosed Glioblastoma

BACKGROUND: Repurposed memantine, mefloquine, and metformin have putative anticancer activity. The objective of this phase 1 study was to determine the maximum tolerated doses (MTDs) of combinations of these agents with temozolomide (TMZ). METHODS: Adults with newly diagnosed glioblastoma who comple...

詳細記述

保存先:
書誌詳細
出版年:Cancer
主要な著者: Maraka, Stefania, Groves, Morris D., Mammoser, Aaron G., Melguizo-Gavilanes, Isaac, Conrad, Charles A., Tremont-Lukats, Ivo W., Loghin, Monica E., O’ Brien, Barbara J., Puduvalli, Vinay K., Sulman, Erik P., Hess, Kenneth R., Aldape, Kenneth D., Gilbert, Mark R., de Groot, John F., Yung, W.K. Alfred, Penas-Prado, Marta
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7180384/
https://ncbi.nlm.nih.gov/pubmed/30359477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.31811
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