Randomized phase II adjuvant factorial study of dose-dense temozolomide alone and in combination with isotretinoin, celecoxib, and/or thalidomide for glioblastoma

BACKGROUND: Chemoradiation, followed by adjuvant temozolomide, is the standard treatment for newly diagnosed glioblastoma. Adding other active agents may enhance treatment efficacy. METHODS: The primary objective of this factorial phase II study was to determine if one of 3 potential chemotherapy ag...

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Udgivet i:Neuro Oncol
Main Authors: Penas-Prado, Marta, Hess, Kenneth R., Fisch, Michael J., Lagrone, Lore W., Groves, Morris D., Levin, Victor A., De Groot, John F., Puduvalli, Vinay K., Colman, Howard, Volas-Redd, Gena, Giglio, Pierre, Conrad, Charles A., Salacz, Michael E., Floyd, Justin D., Loghin, Monica E., Hsu, Sigmund H., Gonzalez, Javier, Chang, Eric L., Woo, Shiao Y., Mahajan, Anita, Aldape, Kenneth D., Yung, W. K. Alfred, Gilbert, Mark R.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Clinical Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288521/
https://ncbi.nlm.nih.gov/pubmed/25239666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou155
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