A phase I factorial design study of dose-dense temozolomide alone and in combination with thalidomide, isotretinoin, and/or celecoxib as postchemoradiation adjuvant therapy for newly diagnosed glioblastoma

External beam radiation therapy (XRT) with concomitant temozolomide and 6 cycles of adjuvant temozolomide (5/28-day schedule) improves survival in patients with newly diagnosed glioblastoma compared with XRT alone. Studies suggest that dose-dense temozolomide schedules and addition of cytostatic age...

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Hauptverfasser: Gilbert, Mark R., Gonzalez, Javier, Hunter, Kathy, Hess, Kenneth, Giglio, Pierre, Chang, Eric, Puduvalli, Vinay, Groves, Morris D., Colman, Howard, Conrad, Charles, Levin, Victor, Woo, Shaio, Mahajan, Anita, de Groot, John, Yung, W.K. Alfred
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
Schlagworte:
Clinical Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098026/
https://ncbi.nlm.nih.gov/pubmed/20729242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq100
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