Copper-Catalyzed Annulation–Cyanotrifluoromethylation of 1,6-Enynes Toward 1-Indanones via a Radical Process

A new Cu(II)-catalyzed annulation–cyanotrifluoromethylation of 1,6-enynes with Togni's reagent and trimethylsilyl cyanide (TMSCN) has been established, enabling the direct construction of trifluoromethylated 1-indanones with an all-carbon quaternary center in good yields. This reaction was perf...

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Bibliographic Details
Published in:Front Chem
Main Authors: Zhang, Tian-Shu, Hao, Wen-Juan, Cai, Pei-Jun, Li, Guigen, Tu, Shu-Jiang, Jiang, Bo
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7180230/
https://ncbi.nlm.nih.gov/pubmed/32363174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00234
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