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Mutations in the Leucine Zipper-Like Motif of the Human Parainfluenza Virus 3 Fusion Protein Impair Fusion Activity

OBJECTIVE: To investigate the effect of the leucine zipper-like motif between HRA and HRB of the human parainfluenza virus 3 fusion protein on fusion activity. METHODS: Site-directed mutagenesis was utilized to substitute the heptadic residues at 257, 264, 271, 278, 285, 292, and 299 in this motif w...

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Dettagli Bibliografici
Pubblicato in:Intervirology
Autori principali: Xie, Wenyan, Wen, Hongling, Chu, Fulu, Yan, Shaofeng, Xie, Wenli, Lin, Bin, Chen, Yuzhen, Li, Zhenmei, Ren, Guijie, Song, Yanyan, Zhao, Li, Wang, Zhiyu
Natura: Artigo
Lingua:Inglês
Pubblicazione: S. Karger AG 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179560/
https://ncbi.nlm.nih.gov/pubmed/26694747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000441978
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