N-Acetyltransferase 2 Genotypes among Zulu-Speaking South Africans and Isoniazid and N-Acetyl-Isoniazid Pharmacokinetics during Antituberculosis Treatment

The distribution of N-acetyltransferase 2 gene (NAT2) polymorphisms varies considerably among different ethnic groups. Information on NAT2 single-nucleotide polymorphisms in the South African population is limited. We investigated NAT2 polymorphisms and their effect on isoniazid pharmacokinetics (PK...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Mthiyane, Thuli, Millard, James, Adamson, John, Balakrishna, Yusentha, Connolly, Cathy, Owen, Andrew, Rustomjee, Roxana, Dheda, Keertan, McIlleron, Helen, Pym, Alexander S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179278/
https://ncbi.nlm.nih.gov/pubmed/31964788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02376-19
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