Human DENND1A.V2 Drives Cyp17a1 Expression and Androgen Production in Mouse Ovaries and Adrenals

The DENND1A locus is associated with polycystic ovary syndrome (PCOS), a disorder characterized by androgen excess. Theca cells from ovaries of PCOS women have elevated levels of a DENND1A splice variant (DENND1A.V2). Forced expression of this variant in normal theca cells increases androgen biosynt...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Teves, Maria E., Modi, Bhavi P., Kulkarni, Rewa, Han, Angela X., Marks, Jamaia S., Subler, Mark A., Windle, Jolene, Newall, Jordan M., McAllister, Jan M., Strauss, Jerome F.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7177906/
https://ncbi.nlm.nih.gov/pubmed/32268539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21072545
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