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Unexpected loss of sensitivity to the nicotinic acetylcholine receptor antagonist activity of mecamylamine and dihydro‐β‐erythroidine in nicotine‐tolerant mice

OBJECTIVES: There is a long‐standing interest in developing nicotinic acetylcholine receptor (nAChR) antagonists for concomitant use with nAChR agonists (e.g., nicotine replacement) as complementary smoking cessation aids. Previous studies demonstrate that daily nicotine treatment confers tolerance...

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Detalhes bibliográficos
Publicado no:Brain Behav
Main Authors: de Moura, Fernando B., Wilkerson, Jenny L., McMahon, Lance R.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7177571/
https://ncbi.nlm.nih.gov/pubmed/32092237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/brb3.1581
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