Unexpected loss of sensitivity to the nicotinic acetylcholine receptor antagonist activity of mecamylamine and dihydro‐β‐erythroidine in nicotine‐tolerant mice

OBJECTIVES: There is a long‐standing interest in developing nicotinic acetylcholine receptor (nAChR) antagonists for concomitant use with nAChR agonists (e.g., nicotine replacement) as complementary smoking cessation aids. Previous studies demonstrate that daily nicotine treatment confers tolerance...

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Publicat a:Brain Behav
Autors principals: de Moura, Fernando B., Wilkerson, Jenny L., McMahon, Lance R.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7177571/
https://ncbi.nlm.nih.gov/pubmed/32092237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/brb3.1581
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