The discriminative stimulus effects of i.v. nicotine in rhesus monkeys: pharmacokinetics and apparent pA(2) analysis with dihydro-β-erythroidine

Quantitative analysis of antagonism is infrequently used to identify nAChRs mediating behavioral effects. Here, nicotine (0.032 mg/kg i.v.) was established as a discriminative stimulus in rhesus monkeys responding under a fixed ratio 5 schedule; pharmacokinetics and underlying nAChR mechanism(s) wer...

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Gepubliceerd in:Neuropharmacology
Hoofdauteurs: Moerke, Megan J., Zhu, Andy Z. X., Tyndale, Rachel F., Javors, Martin A., McMahon, Lance R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385163/
https://ncbi.nlm.nih.gov/pubmed/27940077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2016.12.003
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