Wild‐type FLT3 and FLT3 ITD exhibit similar ligand‐induced internalization characteristics

Class III receptor tyrosine kinases control the development of hematopoietic stem cells. Constitutive activation of FLT3 by internal tandem duplications (ITD) in the juxtamembrane domain has been causally linked to acute myeloid leukaemia. Oncogenic FLT3 ITD is partially retained in compartments of...

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Pubblicato in:J Cell Mol Med
Autori principali: Kellner, Fabienne, Keil, Andreas, Schindler, Katrin, Tschongov, Todor, Hünninger, Kerstin, Loercher, Hannah, Rhein, Peter, Böhmer, Sylvia‐Annette, Böhmer, Frank‐D., Müller, Jörg P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176853/
https://ncbi.nlm.nih.gov/pubmed/32155324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.15132
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