Wild‐type FLT3 and FLT3 ITD exhibit similar ligand‐induced internalization characteristics

Class III receptor tyrosine kinases control the development of hematopoietic stem cells. Constitutive activation of FLT3 by internal tandem duplications (ITD) in the juxtamembrane domain has been causally linked to acute myeloid leukaemia. Oncogenic FLT3 ITD is partially retained in compartments of...

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Bibliografske podrobnosti
izdano v:J Cell Mol Med
Main Authors: Kellner, Fabienne, Keil, Andreas, Schindler, Katrin, Tschongov, Todor, Hünninger, Kerstin, Loercher, Hannah, Rhein, Peter, Böhmer, Sylvia‐Annette, Böhmer, Frank‐D., Müller, Jörg P.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176853/
https://ncbi.nlm.nih.gov/pubmed/32155324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.15132
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