Partial Inhibition of Glycolysis Reduces Atherogenesis Independent of Intraplaque Neovascularization in Mice

OBJECTIVE: Intraplaque neovascularization is an important feature of unstable human atherosclerotic plaques. However, its impact on plaque formation and stability is poorly studied. Because proliferating endothelial cells generate up to 85% of their ATP from glycolysis, we investigated whether pharm...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Perrotta, Paola, Van der Veken, Bieke, Van Der Veken, Pieter, Pintelon, Isabel, Roosens, Laurence, Adriaenssens, Elias, Timmerman, Vincent, Guns, Pieter-Jan, De Meyer, Guido R.Y., Martinet, Wim
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2020
Assuntos:
Basic Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176341/
https://ncbi.nlm.nih.gov/pubmed/32188275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.313692
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