Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death

AIMS: There is a need for animal models of plaque rupture. We previously reported that elastin fragmentation, due to a mutation (C1039G(+/−)) in the fibrillin-1 (Fbn1) gene, promotes atherogenesis and a highly unstable plaque phenotype in apolipoprotein E deficient (ApoE(−/−)) mice on a Western-type...

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Detalhes bibliográficos
Publicado no:Eur Heart J
Main Authors: Van der Donckt, Carole, Van Herck, Jozef L., Schrijvers, Dorien M., Vanhoutte, Greetje, Verhoye, Marleen, Blockx, Ines, Van Der Linden, Annemie, Bauters, Dries, Lijnen, Henri R., Sluimer, Judith C., Roth, Lynn, Van Hove, Cor E., Fransen, Paul, Knaapen, Michiel W., Hervent, Anne-Sophie, De Keulenaer, Gilles W., Bult, Hidde, Martinet, Wim, Herman, Arnold G., De Meyer, Guido R.Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416138/
https://ncbi.nlm.nih.gov/pubmed/24553721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehu041
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