Everolimus Rescues the Phenotype of Elastin Insufficiency in Patient Induced Pluripotent Stem Cell–Derived Vascular Smooth Muscle Cells

OBJECTIVE: Elastin gene deletion or mutation leads to arterial stenoses due to vascular smooth muscle cell (SMC) proliferation. Human induced pluripotent stem cells–derived SMCs can model the elastin insufficiency phenotype in vitro but show only partial rescue with rapamycin. Our objective was to i...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Arterioscler Thromb Vasc Biol
Egile Nagusiak: Kinnear, Caroline, Agrawal, Rahul, Loo, Caitlin, Pahnke, Aric, Rodrigues, Deivid Carvalho, Thompson, Tadeo, Akinrinade, Oyediran, Ahadian, Samad, Keeley, Fred, Radisic, Milica, Mital, Seema, Ellis, James
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Lippincott Williams & Wilkins 2020
Gaiak:
Translational Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176340/
https://ncbi.nlm.nih.gov/pubmed/32212852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.313936
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