Everolimus Rescues the Phenotype of Elastin Insufficiency in Patient Induced Pluripotent Stem Cell–Derived Vascular Smooth Muscle Cells

OBJECTIVE: Elastin gene deletion or mutation leads to arterial stenoses due to vascular smooth muscle cell (SMC) proliferation. Human induced pluripotent stem cells–derived SMCs can model the elastin insufficiency phenotype in vitro but show only partial rescue with rapamycin. Our objective was to i...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Kinnear, Caroline, Agrawal, Rahul, Loo, Caitlin, Pahnke, Aric, Rodrigues, Deivid Carvalho, Thompson, Tadeo, Akinrinade, Oyediran, Ahadian, Samad, Keeley, Fred, Radisic, Milica, Mital, Seema, Ellis, James
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2020
Assuntos:
Translational Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176340/
https://ncbi.nlm.nih.gov/pubmed/32212852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.313936
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