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Inhibitors of Hydrolases with an Acyl–Enzyme Intermediate

Peptidases and esterases are hydrolytic enzymes; 2–3% of all gene products are assigned to this group alone. They are therefore, an important group of target proteins for the design of new medicines and have a special importance for structure-based drug design. This is reflected in the fact that abo...

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Библиографические подробности
Опубликовано в: :Drug Design
Главный автор: Klebe, Gerhard
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176293/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-3-642-17907-5_23
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