Epistatic interactions can moderate the antigenic effect of substitutions in haemagglutinin of influenza H3N2 virus

We previously showed that single amino acid substitutions at seven positions in haemagglutinin determined major antigenic change of influenza H3N2 virus. Here, the impact of two such substitutions was tested in 11 representative H3 haemagglutinins to investigate context-dependence effects. The antig...

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Detaylı Bibliyografya
Yayımlandı:J Gen Virol
Asıl Yazarlar: Koel, Björn F., Burke, David F., van der Vliet, Stefan, Bestebroer, Theo M., Rimmelzwaan, Guus F., Osterhaus, Albert D. M. E., Smith, Derek J., Fouchier, Ron A. M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Microbiology Society 2019
Konular:
Short Communication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176280/
https://ncbi.nlm.nih.gov/pubmed/31017567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.001263
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