Epistatic interactions can moderate the antigenic effect of substitutions in haemagglutinin of influenza H3N2 virus

We previously showed that single amino acid substitutions at seven positions in haemagglutinin determined major antigenic change of influenza H3N2 virus. Here, the impact of two such substitutions was tested in 11 representative H3 haemagglutinins to investigate context-dependence effects. The antig...

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Dades bibliogràfiques
Publicat a:J Gen Virol
Autors principals: Koel, Björn F., Burke, David F., van der Vliet, Stefan, Bestebroer, Theo M., Rimmelzwaan, Guus F., Osterhaus, Albert D. M. E., Smith, Derek J., Fouchier, Ron A. M.
Format: Artigo
Idioma:Inglês
Publicat: Microbiology Society 2019
Matèries:
Short Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176280/
https://ncbi.nlm.nih.gov/pubmed/31017567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.001263
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