Epistatic interactions can moderate the antigenic effect of substitutions in haemagglutinin of influenza H3N2 virus

We previously showed that single amino acid substitutions at seven positions in haemagglutinin determined major antigenic change of influenza H3N2 virus. Here, the impact of two such substitutions was tested in 11 representative H3 haemagglutinins to investigate context-dependence effects. The antig...

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Bibliografske podrobnosti
izdano v:J Gen Virol
Main Authors: Koel, Björn F., Burke, David F., van der Vliet, Stefan, Bestebroer, Theo M., Rimmelzwaan, Guus F., Osterhaus, Albert D. M. E., Smith, Derek J., Fouchier, Ron A. M.
Format: Artigo
Jezik:Inglês
Izdano: Microbiology Society 2019
Teme:
Short Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176280/
https://ncbi.nlm.nih.gov/pubmed/31017567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.001263
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