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Epistatic interactions can moderate the antigenic effect of substitutions in haemagglutinin of influenza H3N2 virus
We previously showed that single amino acid substitutions at seven positions in haemagglutinin determined major antigenic change of influenza H3N2 virus. Here, the impact of two such substitutions was tested in 11 representative H3 haemagglutinins to investigate context-dependence effects. The antig...
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| Publicado no: | J Gen Virol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Microbiology Society
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7176280/ https://ncbi.nlm.nih.gov/pubmed/31017567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.001263 |
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