The oncogene BCL6 is up-regulated in glioblastoma in response to DNA damage, and drives survival after therapy

The prognosis for people with the high-grade brain tumor glioblastoma is very poor, due largely to low cell death in response to genotoxic therapy. The transcription factor BCL6, a protein that normally suppresses the DNA damage response during immune cell maturation, and a known driver of B-cell ly...

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Veröffentlicht in:PLoS One
Hauptverfasser: Fabre, Marie-Sophie, Stanton, Nicole M., Slatter, Tania L., Lee, Samuel, Senanayake, Dinindu, Gordon, Rosemary M. A., Castro, M. Leticia, Rowe, Matthew R., Taha, Ahmad, Royds, Janice A., Hung, Noelyn, Melnick, Ari M., McConnell, Melanie J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176076/
https://ncbi.nlm.nih.gov/pubmed/32320427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0231470
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