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Heteroaryl phosphonates as non-covalent inhibitors of both serine- and metallo-carbapenemases
Gram-negative pathogens expressing serine β-lactamases (SBLs) and metallo-β-lactamases (MBLs), especially those with carbapenemase activity, threaten the clinical utility of almost all β-lactam antibiotics. Here we describe the discovery of a heteroaryl phosphonate scaffold that exhibits non-covalen...
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| Vydáno v: | J Med Chem |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7175962/ https://ncbi.nlm.nih.gov/pubmed/31483651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00728 |
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