Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice

Alcohol consumption is the key risk factor for the development of esophageal squamous cell carcinoma (ESCC), and acetaldehyde, a metabolite of alcohol, is an alcohol-derived major carcinogen that causes DNA damage. Aldehyde dehydrogenase2 (ALDH2) is an enzyme that detoxifies acetaldehyde, and its ac...

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Détails bibliographiques
Publié dans:Carcinogenesis
Auteurs principaux: Hirohashi, Kenshiro, Ohashi, Shinya, Amanuma, Yusuke, Nakai, Yukie, Ida, Tomomi, Baba, Kiichiro, Mitani, Yosuke, Mizumoto, Ayaka, Yamamoto, Yoshihiro, Kikuchi, Osamu, Matsubara, Junichi, Yamada, Atsushi, Miyamoto, Shin’ichi, Seno, Hiroshi, Matsuda, Tomonari, Muto, Manabu
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Carcinogenesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7175241/
https://ncbi.nlm.nih.gov/pubmed/31074772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgz091
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