Effect of Intravenous Zoledronic Acid on Tibiofemoral Cartilage Volume Among Patients With Knee Osteoarthritis With Bone Marrow Lesions: A Randomized Clinical Trial

IMPORTANCE: A proof-of-principle study suggested that intravenous zoledronic acid may reduce knee pain and the size of bone marrow lesions in people with knee osteoarthritis, but data from large trials are lacking. OBJECTIVE: To determine the effects of intravenous zoledronic acid on knee cartilage...

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Detalhes bibliográficos
Publicado no:JAMA
Main Authors: Cai, Guoqi, Aitken, Dawn, Laslett, Laura L., Pelletier, Jean-Pierre, Martel-Pelletier, Johanne, Hill, Catherine, March, Lyn, Wluka, Anita E., Wang, Yuanyuan, Antony, Benny, Blizzard, Leigh, Winzenberg, Tania, Cicuttini, Flavia, Jones, Graeme
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2020
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7175085/
https://ncbi.nlm.nih.gov/pubmed/32315057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2020.2938
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