A protocol for a multicentre, randomised, double-blind, placebo-controlled trial to compare the effect of annual infusions of zoledronic acid to placebo on knee structural change and knee pain over 24 months in knee osteoarthritis patients – ZAP2

BACKGROUND: Bisphosphonates are a class of drugs that slow bone loss and are a promising candidate to treat knee osteoarthritis (OA) patients. In a pilot study, we demonstrated that zoledronic acid reduced knee pain and size of subchondral bone marrow lesions (BMLs) over 6 months in knee OA patients...

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Bibliographic Details
Published in:BMC Musculoskelet Disord
Main Authors: Aitken, Dawn, Laslett, Laura L., Cai, Guoqi, Hill, Catherine, March, Lyn, Wluka, Anita E., Wang, Yuanyuan, Blizzard, Leigh, Cicuttini, Flavia, Jones, Graeme
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
Subjects:
Study Protocol
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052532/
https://ncbi.nlm.nih.gov/pubmed/30021646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-018-2143-2
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