Acetylshikonin suppressed growth of colorectal tumour tissue and cells by inhibiting the intracellular kinase, T‐lymphokine‐activated killer cell‐originated protein kinase.

BACKGROUND AND PURPOSE: Overexpression or aberrant activation of the T‐lymphokine‐activated killer cell‐originated protein kinase (TOPK) promotes gene expression and growth of solid tumours, implying that TOPK would be a rational target in developing novel anticancer drugs. Acetylshikonin, a diterpe...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Zhao, Ran, Choi, Bu Young, Wei, Lixiao, Fredimoses, Mangaladoss, Yin, Fanxiang, Fu, Xiaorong, Chen, Hanyong, Liu, Kangdong, Kundu, Joydeb Kumar, Dong, Zigang, Lee, Mee‐Hyun
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174886/
https://ncbi.nlm.nih.gov/pubmed/31985814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14981
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