An Engineered Pathway for Production of Terminally Sialylated N-glycoproteins in the Periplasm of Escherichia coli

Terminally sialylated N-glycoproteins are of great interest in therapeutic applications. Due to the inability of prokaryotes to carry out this post-translational modification, they are currently predominantly produced in eukaryotic host cells. In this study, we report a synthetic pathway to produce...

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Detalhes bibliográficos
Publicado no:Front Bioeng Biotechnol
Main Authors: Zhu, Jing, Ruan, Yao, Fu, Xin, Zhang, Lichao, Ge, Gaoshun, Wall, J. Gerard, Zou, Teng, Zheng, Yang, Ding, Ning, Hu, Xuejun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Bioengineering and Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174548/
https://ncbi.nlm.nih.gov/pubmed/32351949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.00313
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