Targeted Melanoma Radiotherapy Using Ultrasmall (177)Lu-Labeled α-Melanocyte Stimulating Hormone-Functionalized Core-Shell Silica Nanoparticles

Lutetium-177 ((177)Lu) radiolabeled ultrasmall (~6 nm dia.) fluorescent core-shell silica nanoparticles (Cornell prime dots or C’ dots) were developed for improving efficacy of targeted radiotherapy in melanoma models. PEGylated C’ dots were surface engineered to display 10–15 alpha melanocyte stimu...

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Publicat a:Biomaterials
Autors principals: Zhang, Xiuli, Chen, Feng, Turker, Melik Z., Ma, Kai, Zanzonico, Pat, Gallazzi, Fabio, Shah, Manankumar A., Prater, Austin R., Wiesner, Ulrich, Bradbury, Michelle S., McDevitt, Michael R., Quinn, Thomas P.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7171978/
https://ncbi.nlm.nih.gov/pubmed/32120314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2020.119858
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