RAC1-Dependent ORAI1 Translocation to the Leading Edge Supports Lamellipodia Formation and Directional Persistence

Tumor invasion requires efficient cell migration, which is achieved by the generation of persistent and polarized lamellipodia. The generation of lamellipodia is supported by actin dynamics at the leading edge where a complex of proteins known as the WAVE regulatory complex (WRC) promotes the requir...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lopez-Guerrero, Aida M., Espinosa-Bermejo, Noelia, Sanchez-Lopez, Irene, Macartney, Thomas, Pascual-Caro, Carlos, Orantos-Aguilera, Yolanda, Rodriguez-Ruiz, Lola, Perez-Oliva, Ana B., Mulero, Victoriano, Pozo-Guisado, Eulalia, Martin-Romero, Francisco Javier
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7171199/
https://ncbi.nlm.nih.gov/pubmed/32313105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-63353-5
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