Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

Evidence suggests that fasting exerts extensive antitumor effects in various cancers, including colorectal cancer (CRC). However, the mechanism behind this response is unclear. We investigate the effect of fasting on glucose metabolism and malignancy in CRC. We find that fasting upregulates the expr...

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Publié dans:Nat Commun
Auteurs principaux: Weng, Mei-lin, Chen, Wan-kun, Chen, Xiang-yuan, Lu, Hong, Sun, Zhi-rong, Yu, Qi, Sun, Peng-fei, Xu, Ya-jun, Zhu, Min-min, Jiang, Nan, Zhang, Jin, Zhang, Jian-ping, Song, Yuan-lin, Ma, Duan, Zhang, Xiao-ping, Miao, Chang-hong
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170903/
https://ncbi.nlm.nih.gov/pubmed/32313017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15795-8
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