Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

Evidence suggests that fasting exerts extensive antitumor effects in various cancers, including colorectal cancer (CRC). However, the mechanism behind this response is unclear. We investigate the effect of fasting on glucose metabolism and malignancy in CRC. We find that fasting upregulates the expr...

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Publicado en:Nat Commun
Main Authors: Weng, Mei-lin, Chen, Wan-kun, Chen, Xiang-yuan, Lu, Hong, Sun, Zhi-rong, Yu, Qi, Sun, Peng-fei, Xu, Ya-jun, Zhu, Min-min, Jiang, Nan, Zhang, Jin, Zhang, Jian-ping, Song, Yuan-lin, Ma, Duan, Zhang, Xiao-ping, Miao, Chang-hong
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170903/
https://ncbi.nlm.nih.gov/pubmed/32313017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15795-8
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