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Voltage-Dependent Protonation of the Calcium Pocket Enable Activation of the Calcium-Activated Chloride Channel Anoctamin-1 (TMEM16A)
Anoctamin-1 (ANO1 or TMEM16A) is a homo-dimeric Ca(2+)-activated Cl(−) channel responsible for essential physiological processes. Each monomer harbours a pore and a Ca(2+)-binding pocket; the voltage-dependent binding of two intracellular Ca(2+) ions to the pocket gates the pore. However, in the abs...
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| Veröffentlicht in: | Sci Rep |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7170896/ https://ncbi.nlm.nih.gov/pubmed/32313203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62860-9 |
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