Extracellular protons enable activation of the calcium‐dependent chloride channel TMEM16A

KEY POINTS: The calcium‐activated chloride channel TMEM16A provides a pathway for chloride ion movements that are key in preventing polyspermy, allowing fluid secretion, controlling blood pressure, and enabling gastrointestinal activity. TMEM16A is opened by voltage‐dependent calcium binding and reg...

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Détails bibliographiques
Publié dans:J Physiol
Auteurs principaux: Cruz‐Rangel, Silvia, De Jesús‐Pérez, José J., Aréchiga‐Figueroa, Iván A., Rodríguez‐Menchaca, Aldo A., Pérez‐Cornejo, Patricia, Hartzell, H. Criss, Arreola, Jorge
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2017
Sujets:
Molecular and cellular
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330900/
https://ncbi.nlm.nih.gov/pubmed/27859335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273111
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