Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin

Streptococcus pneumoniae serotype 1 is the predominant cause of invasive pneumococcal disease in sub-Saharan Africa, but the mechanism behind its increased invasiveness is not well understood. Here, we use mouse models of lung infection to identify virulence factors associated with severe bacteraemi...

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Vydáno v:Nat Commun
Hlavní autoři: Jacques, Laura C., Panagiotou, Stavros, Baltazar, Murielle, Senghore, Madikay, Khandaker, Shadia, Xu, Rong, Bricio-Moreno, Laura, Yang, Marie, Dowson, Christopher G., Everett, Dean B., Neill, Daniel R., Kadioglu, Aras
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170840/
https://ncbi.nlm.nih.gov/pubmed/32312961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15751-6
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