Pneumolysin binds to the Mannose-Receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival

Streptococcus pneumoniae (the pneumococcus) is a major cause of mortality and morbidity globally, and the leading cause of death in under-five year olds. The pneumococcal cytolysin pneumolysin (PLY) is a major virulence determinant, known to induce pore-dependent pro-inflammatory responses. These in...

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Udgivet i:Nat Microbiol
Main Authors: Subramanian, Karthik, Neill, Daniel R, Malak, Hesham, Spelmink, Laura, Khandaker, Shadia, Marchiori, Giorgia Dalla Libera, Dearing, Emma, Kirby, Alun, Yang, Marie, Achour, Adnane, Nilvebrant, Johan, Nygren, Per-Åke, Plant, Laura, Kadioglu, Aras, Henriques-Normark, Birgitta
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298590/
https://ncbi.nlm.nih.gov/pubmed/30420782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-018-0280-x
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