Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly-identified brain sterol metabolite, galactosylated cholesterol

β-Glucocerebrosidase (GBA) hydrolyzes glucosylceramide (GlcCer) to generate ceramide. Previously, we demonstrated that lysosomal GBA1 and nonlysosomal GBA2 possess not only GlcCer hydrolase activity, but also transglucosylation activity to transfer the glucose residue from GlcCer to cholesterol to f...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Akiyama, Hisako, Ide, Mitsuko, Nagatsuka, Yasuko, Sayano, Tomoko, Nakanishi, Etsuro, Uemura, Norihito, Yuyama, Kohei, Yamaguchi, Yoshiki, Kamiguchi, Hiroyuki, Takahashi, Ryosuke, Aerts, Johannes M. F. G., Greimel, Peter, Hirabayashi, Yoshio
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Lipids
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170530/
https://ncbi.nlm.nih.gov/pubmed/32144204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012502
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