Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly-identified brain sterol metabolite, galactosylated cholesterol

β-Glucocerebrosidase (GBA) hydrolyzes glucosylceramide (GlcCer) to generate ceramide. Previously, we demonstrated that lysosomal GBA1 and nonlysosomal GBA2 possess not only GlcCer hydrolase activity, but also transglucosylation activity to transfer the glucose residue from GlcCer to cholesterol to f...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Biol Chem
Main Authors: Akiyama, Hisako, Ide, Mitsuko, Nagatsuka, Yasuko, Sayano, Tomoko, Nakanishi, Etsuro, Uemura, Norihito, Yuyama, Kohei, Yamaguchi, Yoshiki, Kamiguchi, Hiroyuki, Takahashi, Ryosuke, Aerts, Johannes M. F. G., Greimel, Peter, Hirabayashi, Yoshio
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2020
נושאים:
Lipids
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170530/
https://ncbi.nlm.nih.gov/pubmed/32144204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012502
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