Targeted alpha therapy using astatine ((211)At)-labeled phenylalanine: A preclinical study in glioma bearing mice

Phenylalanine derivatives, which target tumors especially through L-type amino acid transporter-1 (LAT1), have elicited considerable attention. In this study, we evaluated the treatment effect of phenylalanine labeled with the alpha emitter astatine ((211)At-PA) in tumor bearing mice. The C6 glioma,...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Watabe, Tadashi, Kaneda-Nakashima, Kazuko, Shirakami, Yoshifumi, Liu, Yuwei, Ooe, Kazuhiro, Teramoto, Takahiro, Toyoshima, Atsushi, Shimosegawa, Eku, Nakano, Takashi, Kanai, Yoshikatsu, Shinohara, Atsushi, Hatazawa, Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170498/
https://ncbi.nlm.nih.gov/pubmed/32341757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27552
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