Neurokinin-1 Receptor Signaling Is Required for Efficient Ca(2+) Flux in T-Cell-Receptor-Activated T Cells

Efficient Ca(2+) flux induced during cognate T cell activation requires signaling the T cell receptor (TCR) and unidentified G-protein-coupled receptors (GPCRs). T cells express the neurokinin-1 receptor (NK1R), a GPCR that mediates Ca(2+) flux in excitable and non-excitable cells. However, the role...

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Udgivet i:Cell Rep
Main Authors: Morelli, Adrian E., Sumpter, Tina L., Rojas-Canales, Darling M., Bandyopadhyay, Mohna, Chen, Zhizhao, Tkacheva, Olga, Shufesky, William J., Wallace, Callen T., Watkins, Simon C., Berger, Alexandra, Paige, Christopher J., Falo, Louis D., Larregina, Adriana T.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7169378/
https://ncbi.nlm.nih.gov/pubmed/32160549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.02.054
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