Autocrine hemokinin-1 functions as endogenous adjuvant for IgE-mediated mast cell inflammatory responses

BACKGROUND: Efficient development of atopic diseases requires interaction between allergen and adjuvant to initiate and amplify underlying inflammatory responses. Substance P (SP) and hemokinin-1 (HK-1) are neuropeptides that signal via the neurokinin-1 receptor (NK1R) to promote inflammation. Mast...

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Publicado no:J Allergy Clin Immunol
Main Authors: Sumpter, Tina L., Ho, Chin H., Pleet, Anna R., Tkacheva, Olga A., Shufesky, William J., Rojas-Canales, Darling M., Morelli, Adrian E., Larregina, Adriana T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362795/
https://ncbi.nlm.nih.gov/pubmed/25201259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.07.036
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