Neurokinin-1 receptor agonists bias therapeutic dendritic cells to induce type 1 immunity by licensing host dendritic cells to produce IL-12

Substance-P and hemokinin-1 are proinflammatory neuropeptides with potential to promote type 1 immunity through agonistic binding to neurokinin-1 receptor (NK1R). Dendritic cells (DCs) are professional antigen-presenting cells that initiate and regulate the outcome of innate and adaptive immune resp...

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Autors principals: Janelsins, Brian M., Sumpter, Tina L., Tkacheva, Olga A., Rojas-Canales, Darling M., Erdos, Geza, Mathers, Alicia R., Shufesky, William J., Storkus, Walter J., Falo, Louis D., Morelli, Adrian E., Larregina, Adriana T.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2013
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624938/
https://ncbi.nlm.nih.gov/pubmed/23365459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-07-446054
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