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Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects
PURPOSE: Dexmedetomidine is an α(2)-adrenoceptor agonist used for perioperative and intensive care sedation. This study develops mechanism-based population pharmacokinetic-pharmacodynamic models for the cardiovascular and central nervous system (CNS) effects of intravenously (IV) and intranasally (I...
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| Publicado no: | Eur J Clin Pharmacol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7167593/ https://ncbi.nlm.nih.gov/pubmed/26233335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-015-1913-0 |
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