H and L Chain Affinity Maturation and/or Fab N-Glycosylation Influence Immunoreactivity toward Neutrophil Extracellular Trap Antigens in Rheumatoid Arthritis Synovial B Cell Clones

We previously showed that anti–neutrophil extracellular trap (NET) rheumatoid arthritis (RA)-rmAbs derived from CD19(+) B cells within RA human synovial tissues frequently react against NETs. In this study, we aimed to characterize the importance of affinity maturation via somatic hypermutation (SHM...

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Detaylı Bibliyografya
Yayımlandı:J Immunol
Asıl Yazarlar: Corsiero, Elisa, Carlotti, Emanuela, Jagemann, Lucas, Perretti, Mauro, Pitzalis, Costantino, Bombardieri, Michele
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: AAI 2020
Konular:
Autoimmunity
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7167462/
https://ncbi.nlm.nih.gov/pubmed/32221039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901457
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