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H and L Chain Affinity Maturation and/or Fab N-Glycosylation Influence Immunoreactivity toward Neutrophil Extracellular Trap Antigens in Rheumatoid Arthritis Synovial B Cell Clones
We previously showed that anti–neutrophil extracellular trap (NET) rheumatoid arthritis (RA)-rmAbs derived from CD19(+) B cells within RA human synovial tissues frequently react against NETs. In this study, we aimed to characterize the importance of affinity maturation via somatic hypermutation (SHM...
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| Publicado no: | J Immunol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
AAI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7167462/ https://ncbi.nlm.nih.gov/pubmed/32221039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901457 |
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