Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs

OBJECTIVES: Rheumatoid arthritis (RA) is characterised by breach of self-tolerance towards citrullinated antigens with generation of anti-citrullinated peptide/proteins antibodies (ACPA). Currently, the nature and source of citrullinated antigens driving the humoral autoimmune response within synovi...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Corsiero, Elisa, Bombardieri, Michele, Carlotti, Emanuela, Pratesi, Federico, Robinson, William, Migliorini, Paola, Pitzalis, Costantino
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036240/
https://ncbi.nlm.nih.gov/pubmed/26659717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-208356
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