Ivacaftor decreases monocyte sensitivity to interferon-γ in people with cystic fibrosis

This study demonstrates that initiation of the CFTR modulator ivacaftor in people with cystic fibrosis and susceptible CFTR mutations causes an acute reduction in blood monocyte sensitivity to the key proinflammatory cytokine IFN-γ http://bit.ly/2TeI6LG

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Bibliographic Details
Published in:ERJ Open Res
Main Authors: Hisert, Katherine B., Birkland, Timothy P., Schoenfelt, Kelly Q., Long, Matthew E., Grogan, Brenda, Carter, Suzanne, Liles, W. Conrad, McKone, Edward F., Becker, Lev, Manicone, Anne M.
Format: Artigo
Language:Inglês
Published: European Respiratory Society 2020
Subjects:
Original Research Letters
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7167213/
https://ncbi.nlm.nih.gov/pubmed/32337217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/23120541.00318-2019
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