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MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease

Polyglutamine (polyQ) tract expansion leads to proteotoxic misfolding and drives a family of nine diseases. We study spinal and bulbar muscular atrophy (SBMA), a progressive degenerative disorder of the neuromuscular system caused by the polyQ androgen receptor (AR). Using a knock-in mouse model of...

詳細記述

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書誌詳細
出版年:Acta Neuropathol
主要な著者: Nath, Samir R., Lieberman, Matthew L., Yu, Zhigang, Marchioretti, Caterina, Jones, Samuel T., Danby, Emily C. E., Van Pelt, Kate M., Sorarù, Gianni, Robins, Diane M., Bates, Gillian P., Pennuto, Maria, Lieberman, Andrew P.
フォーマット: Artigo
言語:Inglês
出版事項: Springer Berlin Heidelberg 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7166004/
https://ncbi.nlm.nih.gov/pubmed/32306066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02156-4
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