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MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease
Polyglutamine (polyQ) tract expansion leads to proteotoxic misfolding and drives a family of nine diseases. We study spinal and bulbar muscular atrophy (SBMA), a progressive degenerative disorder of the neuromuscular system caused by the polyQ androgen receptor (AR). Using a knock-in mouse model of...
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| 出版年: | Acta Neuropathol |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer Berlin Heidelberg
2020
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7166004/ https://ncbi.nlm.nih.gov/pubmed/32306066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02156-4 |
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